5-AMINO-1MQ Suspension 30mg/ml – 50ml

5-AMINO-1MQ Suspension 30mg/ml – 50ml

What Is 5-AMINO-1MQ?

5-AMINO-1MQ (5-Amino-1-methylquinolinium) is a small molecule inhibitor of NNMT (Nicotinamide N-methyltransferase) — an enzyme that regulates NAD+ metabolism and plays a central role in adipogenesis, metabolic rate, and the epigenetic silencing of differentiation genes in adipose progenitor cells. NNMT transfers a methyl group from SAM (S-adenosylmethionine) to nicotinamide, converting it to 1-methylnicotinamide. By inhibiting this process, 5-AMINO-1MQ raises intracellular NAD+ and SAM levels while simultaneously depleting the methyl-consuming pathway — effectively reprogramming adipocyte gene expression toward fat mobilization and reduced lipid storage.

Research in obese rodent models has demonstrated that 5-AMINO-1MQ reduces body weight, reduces fat mass, and improves metabolic markers without changes in food intake or activity levels. It represents a mechanistically distinct approach to metabolic research compared to PPARδ agonists or Rev-ErbA modulators, working directly on the NAD+/methylation axis rather than transcription factor pathways.

Mechanism of Action

NNMT is highly expressed in adipose tissue where it acts as a brake on energy expenditure and a promoter of adipogenesis. 5-AMINO-1MQ competitively inhibits NNMT, causing cellular NAD+ levels to rise (activating SIRT1 and other NAD+-dependent deacetylases) while also elevating SAM. The combined effect is activation of brown fat-like gene expression programs, increased metabolic rate, and suppression of white adipose differentiation — all without requiring dietary restriction.

Research Applications

• Obesity and fat mass reduction: NAD+/NNMT axis modulation for metabolic intervention research.
• NAD+ metabolism: Tool compound for studying NNMT inhibition alongside NMN supplementation research.
• Adipogenesis: Reprogramming of adipocyte differentiation gene expression programs.
• Epigenetics: SAM-mediated methylation changes in adipose tissue chromatin.

Related Research Compounds

5-AMINO-1MQ is most meaningfully studied alongside NMN (Nicotinamide Mononucleotide) — both target the NAD+ biosynthesis axis but through completely different mechanisms (NMN provides NAD+ precursor; 5-AMINO-1MQ inhibits NAD+ consumption via NNMT). For complementary metabolic research comparing nuclear receptor-based approaches, see GW501516 (Cardarine) and SR9009.

⚠ This product is a suspension — shake well before use. For laboratory research use only. Not for human or animal consumption.