MK-677 Ibutamoren Solution 25mg/ml – 50ml
| Application | A potent, non-peptide ghrelin receptor agonist |
| Concentration | 2.5% (25mg/ml) |
| Composition | 5% ethanol, 92.5% deionized water, 2.5% MK-677 (>99% purity) |
| CAS | 159752-10-0 |
| Molar Mass | 528.662 g/mol |
| Chemical Formula | C27H36N4O5S |
| Synonyms | Ibutamoren, MK-677, MK-0677, L-163,191, Nutrobal |
| Storage | Minimize open air exposure, store in a cool dry place |
| Terms | The products we offer are intended for laboratory research use only. Please familiarize yourself with our Terms & Conditions prior to ordering. |
What Is MK-677 (Ibutamoren)?
MK-677, also known as Ibutamoren or Nutrobal, is an orally active, non-peptide ghrelin receptor agonist that stimulates growth hormone (GH) secretion and elevates insulin-like growth factor 1 (IGF-1) levels. Unlike peptide-based GH secretagogues that require injection, MK-677 is orally bioavailable and maintains elevated GH/IGF-1 levels for up to 24 hours per dose — making it exceptionally practical for longitudinal laboratory research designs.
First developed as an investigational compound for muscle-wasting conditions and growth hormone deficiency, MK-677 has been studied in multiple human Phase 1 and Phase 2 trials. Research has demonstrated dose-dependent increases in IGF-1 of 40–89%, improvements in sleep architecture (particularly REM duration), and potential benefits in bone mineral density and lean body mass — all without significant cortisol elevation.
Mechanism of Action
MK-677 binds to the growth hormone secretagogue receptor (GHSR-1a) in the pituitary and hypothalamus, mimicking the endogenous ligand ghrelin. This triggers pulsatile GH release while preserving the natural feedback inhibition of the GH axis — a clinically meaningful distinction from exogenous GH administration. The resulting sustained IGF-1 elevation underpins the compound’s anabolic and metabolic research applications.
Research Applications
- Muscle preservation: Studies in elderly and GH-deficient populations examine MK-677’s ability to attenuate sarcopenia and cachexia.
- Bone density: IGF-1 directly stimulates osteoblast activity; MK-677 is studied in osteoporosis models.
- Sleep research: Clinical data show significant improvements in REM sleep duration at low doses.
- Cognitive function: GH/IGF-1 axis stimulation is investigated in neurodegeneration models.
Related Research Compounds
MK-677 is frequently studied alongside RAD-140 (Testolone) and LGD-4033 (Ligandrol) in dual-mechanism anabolic study designs — pairing GH/IGF-1 axis activation with selective androgen receptor agonism. For metabolic co-administration designs, researchers often include GW501516 (Cardarine) or SR9009 (Stenabolic). For powder-format research, see the Ibutamoren MK-677 Powder (1g).
Read our full research guide: MK-677 (Ibutamoren) – How It Works, Research Findings & What to Know.
For laboratory research use only. Not for human or animal consumption.
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