RU58841 | RU-58841 Solution 50mg/ml – 50ml
| Application | Non-steroidal androgen receptor antagonist |
| Concentration | 5% (50mg/ml) |
| Composition | 95% Ethanol, 5% RU-58841 (>99% purity) |
| CAS | 154992-24-2 |
| Molar Mass | 369.33 g/mol |
| Chemical Formula | C17H18F3N3O3 |
| Synonyms | RU-58841, HMR-3690, PSK-3841 |
| Storage | Minimize open air exposure, store in a cool dry place. Refrigerate for long-term storage. |
| Terms | For laboratory research use only. Not for human or animal consumption. |
What Is RU58841?
RU58841 (also known as HMR-3690 or PSK-3841) is a non-steroidal, topically active androgen receptor antagonist originally developed by Roussel Uclaf and investigated for androgenetic alopecia (AGA). Unlike systemic AR antagonists such as finasteride (which targets 5α-reductase) or systemic antiandrogens, RU58841 was designed for topical administration to act locally at androgen-sensitive hair follicles in the scalp while minimizing systemic androgenic effects — a research model with important implications for both hair loss biology and the study of androgen receptor function in dermal tissue.
RU58841 competes directly with DHT for binding at the androgen receptor within hair follicles. By occupying the AR without activating downstream transcription, it prevents DHT-mediated follicular miniaturization. In animal models, topical application prevented hair loss in androgen-treated macaques and testosterone-treated stump-tailed macaques — among the most predictive preclinical models for human AGA.
Mechanism of Action
RU58841 binds the AR with high affinity and acts as a competitive antagonist, blocking DHT’s ability to activate the receptor in scalp follicles. Its relatively high lipophilicity facilitates dermal penetration from topical vehicles, while its shorter half-life and rapid metabolic inactivation in systemic circulation limit off-target androgenic disruption. This pharmacokinetic profile makes it an ideal research tool for studying localized androgen receptor blockade without the confounding systemic effects of older-generation antiandrogens.
Research Applications
- Androgenetic alopecia: Standard tool compound in preclinical hair loss research; validated in macaque and rodent models.
- Follicular AR pharmacology: Studies of androgen receptor expression and signaling in dermal papilla cells.
- Topical antiandrogen dosing: Vehicle formulation optimization for scalp-targeting androgen receptor blockade.
- Comparative AR antagonism: Benchmark comparison with systemic antiandrogens in tissue-selective activity studies.
Related Research Compounds
RU58841 is compared to other androgenetic alopecia research tools and to systemic AR modulators including MK-2866 (Ostarine) and Andarine (S4) in studies examining the spectrum of AR agonism vs antagonism. Also available in powder format: RU58841 Powder (5g).
For laboratory research use only. Not for human or animal consumption.
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