Myo-lnositol Trispyrophosphate (ITPP) Sodium Powder 1g

Myo-lnositol Trispyrophosphate (ITPP) Sodium Powder 1g

Myo-Inositol Trispyrophosphate (ITPP) is a compound widely studied as an allosteric effector of hemoglobin in in vitro biochemical research. To confirm its 99%+ purity and validate its molecular structure, this batch has undergone third-party testing by an accredited laboratory:

• FTIR: Spectrum matches certified reference standard
• UHPLC: 99.86% purity

What Is ITPP?

Myo-inositol trispyrophosphate (ITPP) is a membrane-permeant allosteric effector of haemoglobin. It enters red blood cells and raises the P50 of haemoglobin, shifting the oxygen-dissociation curve so that more oxygen is released to hypoxic tissues. This makes it a widely used tool compound in hypoxia, exercise-physiology, and oxygen-delivery research.

Mechanism & Research Context

ITPP binds within the central cavity of deoxyhaemoglobin, stabilising the T-state and lowering oxygen affinity. The net effect is enhanced tissue oxygenation under hypoxic conditions, studied in models of ischaemia, tumour hypoxia, and cardiac and skeletal-muscle performance.

Working With the Powder

Supplied as the water-soluble sodium salt, ITPP is suitable for aqueous vehicle preparation. Weigh on a calibrated balance and store cool and dry.

Research Applications

• Tissue oxygenation: hypoxia and ischaemia models; oxygen-dissociation curve shifts.
• Exercise physiology: oxygen-delivery and endurance research.
• Tumour hypoxia: oxygenation of hypoxic microenvironments in oncology models.

Related Products

Metabolic and endurance comparators: GW501516 (Cardarine) and SR9009.

For laboratory research use only. Not for human or animal consumption.