SLU-PP-332 Solution 200 mcg/ml – 50ml

SLU-PP-332 Solution 200 mcg/ml – 50ml

What Is SLU-PP-332?

SLU-PP-332 is a pan-ERR (estrogen-related receptor) agonist developed at St. Louis University that activates all three ERR subtypes — ERRα, ERRβ, and ERRγ. These orphan nuclear receptors are key regulators of mitochondrial biogenesis, oxidative phosphorylation, and fatty acid oxidation in skeletal muscle and cardiac tissue. SLU-PP-332 has attracted significant scientific attention as an “exercise mimetic” — a compound that can replicate certain transcriptional programs activated by physical exercise without actual locomotor activity.

A 2023 study demonstrated that SLU-PP-332 dramatically increased running endurance in mice by 70% compared to controls, while simultaneously protecting cardiac tissue from ischemia-reperfusion injury. The compound activates the same mitochondrial gene expression programs triggered by endurance training, including upregulation of PGC-1α, TFAM, and cytochrome c oxidase subunits — making it a powerful tool for studying exercise-induced adaptations in muscle and heart.

Mechanism: ERR Activation and Mitochondrial Biogenesis

ERRs act as constitutively active transcription factors that bind to ERR response elements (ERREs) in the promoters of genes encoding mitochondrial proteins, fatty acid oxidation enzymes, and oxidative phosphorylation components. SLU-PP-332 acts as a coactivator-mimetic agonist, driving the transcriptional programs that increase mitochondrial number, improve substrate oxidation efficiency, and enhance cardiac and skeletal muscle function under both normal and pathological conditions.

Research Applications

• Exercise mimetics: Endurance enhancement without training; validated in rodent treadmill models.
• Cardiac protection: Reduced infarct size and improved left ventricular function in ischemia-reperfusion models.
• Mitochondrial biology: Pan-ERR activation for studying mitochondrial biogenesis across tissue types.
• Obesity/metabolic disease: Fatty acid oxidation enhancement and improved metabolic flexibility.

Related Research Compounds

SLU-PP-332’s ERR-mediated mechanism is distinct from both PPARδ agonists like GW501516 (Cardarine) and GW0742, and Rev-ErbA agonists like SR9009. Using all three classes together allows researchers to probe complementary but mechanistically distinct exercise-mimetic pathways in the same study design. For anabolic endpoints, RAD-140 or Ostarine provide a SARM comparison arm.

For laboratory research use only. Not for human or animal consumption.