CDP Choline Powder – 50g

CDP Choline Powder – 50g

What Is CDP Choline (Citicoline)?

CDP-Choline (Citicoline, Cytidine 5′-diphosphocholine) is a naturally occurring intermediate in the biosynthesis of phosphatidylcholine — the most abundant phospholipid in neuronal cell membranes. As a research compound, it is a well-characterized choline precursor and neuroprotectant that delivers two active metabolites upon oral administration: choline (a direct acetylcholine precursor) and cytidine (which converts to uridine in the brain, supporting phospholipid membrane synthesis, RNA production, and synaptic protein expression).

Unlike simple choline sources, citicoline’s cytidine component adds a second dimension of neurological activity: uridine activates P2Y receptors and integrates into neuronal membrane phospholipid synthesis via the Kennedy pathway, enhancing synaptic membrane integrity and supporting dendritic spine density — effects that underlie its neuroprotective properties in stroke and neurodegeneration models.

Key Research-Demonstrated Effects

• Dopamine receptor upregulation: Increases striatal D1 and D2 receptor density — a unique property not shared by most cholinergic compounds, relevant for addiction and neurodegeneration research.
• Stroke and ischemia protection: Reduces cerebral infarct volume and improves neurological outcomes in rodent stroke models; extensive human stroke trial history (ICTUS trial).
• Acetylcholine synthesis support: Provides choline substrate to enhance ACh production in conditions of cholinergic deficit.
• Membrane synthesis: Uridine-mediated phosphatidylcholine and synaptic membrane component synthesis.

Related Products

Cholinergic partners: Coluracetam Powder (1g) (HACU enhancer) and Vinpocetine Powder (5g) (cerebrovascular support). Glutamatergic comparators: Noopept Powder, Sunifiram Powder. Read: Cholinergic Nootropics in Research. For laboratory research use only.