Unifiram Powder – 1g

Unifiram Powder – 1g

Unifiram Powder for Research

Unifiram (DM-232) is a piperazinone-derived AMPAkine closely related to Sunifiram (DM-235), sharing the same fundamental mechanism of AMPA receptor positive allosteric modulation and high cognitive potency (approximately 1,000× piracetam per mass unit in rodent cognition assays). Both compounds also activate NMDA receptor function via PKC-mediated GluN2B phosphorylation and enhance acetylcholine release — providing dual glutamatergic and cholinergic cognitive enhancement profiles.

The structural distinction between Unifiram and Sunifiram is a single methyl group difference in their piperazinone side chains. Both compounds show highly similar efficacy in amnesia reversal models. Unifiram may have slightly different receptor kinetics and time-to-peak profiles, though head-to-head pharmacological studies are limited. For research programs where cross-study comparability with Sunifiram is not required, Unifiram offers an equivalent AMPAkine tool compound at a different cost profile.

Research Applications

• Amnesia reversal: Effective against scopolamine, baclofen, and ECS-induced amnesia in rodent models.
• LTP enhancement: AMPA/NMDA dual potentiation for studying glutamatergic memory consolidation mechanisms.
• AMPAkine comparison studies: Direct comparison with Sunifiram for receptor kinetics, dose-response, and behavioral outcomes.
• Multi-mechanism panels: Complements CDP Choline, NSI-189, and Noopept.

Related Products

Structural analog: Sunifiram Powder (10g). Read our guide: Sunifiram & Unifiram Research Guide: AMPAkine Mechanisms and Cognitive Applications. For laboratory research use only.